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Sunday - 2 October 2022
Pre-conference Workshop

Registration and Arrival Refreshments

Pre-conference workshop Chair:
09:15 Welcome Catherine Worsley/Theresa Rossouw
09:30 - 10:15 Getting published: From an author's perspective Catherine Worsley University of Pretoria
10:15 - 11:00 Getting published: From an editor's perspective Elizabeth Mayne University of Cape Town
11:00 - 11:30 Refreshment Break
11:30 - 12:15 Relevant statistical practices in Immunology Pieter Meyer University of Pretoria
12:15 - 13:00 Applying for funding Lindokuhle Ndlandla Medical Research Council

13:00 - 14:00 Lunch
Opening Plenary
14:00 Introduction Conference chair: Catherine Worsley

Welcome: SAIS President Theresa Rossouw Univeristy of Pretoria
Session 1: Plenary Chair: Theresa Rossouw
14:15 - 15:00 Study of adaptive immune responses to SARS CoV-2 and its variants Alessandro Sette La Jolla Institute, UCLA
15:00 - 15:45 Milder disease with Omicron: is it the virus, pre-existing immunity, and will our immunity protect us from the next variant? Alex Sigal AHRI
Session 2: Vaccinology: Re-boosted Chair: Catherine Worsley
16:00 - 16:45 How vaccines train the immune system in ways we do not expect
Sponsored by: Sanofi
Christine Benn University of Southern Denmark
16:45 - 17:15 Vaccine research in Africa Anna-Lise Williamson University of Cape Town


Monday - 3 October 2022
07:00 Registration and Arrival Refreshments
Session 3: COVID Chair: Clive Gray
08:15 - 09:00 T cell responses to COVID-19 vaccines in people living with HIV Wendy Burgers University of Cape Town
09:00 - 09:25 Impact of SARS-CoV-2 exposure history on T cell response Catherine Riou University of Cape Town
09:25 - 09:50 Immune responses to SARS-CoV-2 in children Roanne Keeton University of Cape Town
09:50-10:00 Talks from submitted abstracts - Does COVID-19 infection alter MTB-specific T cell response Hygon Mutavhatsindi
10:00-10:10 Talks from submitted abstracts - ACE2 and the renin angiotensin system in COVID-19: outcome predictors across the spectrum of disease in a South African cohort Talitha Muller

10:15 - 10:45 Refreshment Break
Session 4: In the clinic Chair: Susan Louw
10:50 - 11:15 The immunology of the COVID related multi-system immune syndrome in children Kate Webb University of Cape Town
11:15 - 11:40 Immune profiling of delayed hypersensitivity reactions in TB drugs in HIV co-infected patients Jonny Peter University of Cape Town
11:40 - 12:05 The puzzle of PNH Lindsay Earlam Lancet
12:05 - 12:30 The story of a patient with unexplained mycobacterium avium-intracellulare infection. Using next generation sequencing to resolve challenging diagnoses Tracey Wiggill University of the Witwatersrand
12:30 - 12:40 Talks from submitted abstracts - Antigen-specific immune responses in healthcare workers with resistance to Mycobacterium tuberculosis infection despite sustained occupational exposure Muki Shey
12:40 - 12:50 Talks from submitted abstracts - Changes in NK cell phenotypes in TB/HIV co-infection Thando Maseko
13:00 - 14:00 LUNCH
Session 5: It's in our genes - Autoimmunity and inborn errors of immunity Chair: Pieter Meyer
14:00 - 14:25 DNA repair defects in inborn errors of immunity Roshini Abraham Ohio State
14:25 - 14:50 Advances in  the understanding immunopathogenesis and drug therapies in rheumatoid arthritis Mohammed Tikly University of the Witwatersrand
14:50 - 15:15 Something old, and always something new - Immunodeficiency patients are our teachers Monika Esser SUN
15:15 - 15:25 Talks from submitted abstracts - Biomarker-based approaches show promise in the diagnosis of tuberculosis meningitis in children Novel Chegou
15:25 - 15:50 Refreshment Break
Session 6: Immuno-oncology Chair: Elizabeth Mayne
15:50 - 16:15 Immunotherapy Bernardo Rapoport Rosebank Oncology
16:15 - 16:40 The role of the tumour microenvironment in immune evasion Catherine Worsley University of Pretoria
16:40 - 16:50 Talks from submitted abstracts - Metastatic breast cancer is associated with increased levels of soluble inhibitory immune checkpoint proteins and decreased levels of soluble stimulatory immune checkpoint proteins Teresa Smit
16:50 - 17:00 Talks from submitted abstracts - Recombinant CD64 directed single-chain antibody fusion protein exhibits cytotoxicity and is a tool for site-specific diagnosisof acute myeloid leukemia Sikozile Ncembu

17:15 SAIS AGM
19:00 GALA DINNER - Carnivore Restaurant


Tuesday - 4 October 2022
07:00 Registration and Arrival Refreshments
Session 7: Transplantation, transfusion, and cellular therapeutics Chair: Luyanda Kwofie
08:00 - 08:25 The future of CART is allogeneic - our journey Michael Pepper University of Pretoria
08:25 - 08:50 Transfusion and Transplantation: from Donor to Recipient Riana Cockeran SANBS
08:50 - 09:15 The South African Bone Marrow Registry - evolving changes Charlotte Ingram SABMR
Session 8: Veterinary immunology Chair: Luyanda Kwofie
09:15 - 09:40 Interferon-gamma-induced biomarkers of Mycobacterium bovis infection in African wildlife Sven Parsons Afrivet
09:40 - 09:55 Talks from submitted abstracts: A Comparative immunological profile of Babesia microti infected BALB/c mice co-infested with Ixodes ricinus ticks and its effect on immunisation. Christine Maritz-Olivier University of Pretoria

10:00 - 10:25 Refreshment Break
Session 9: Infectious diseases Chair: Heena Ranchod
10:25 - 10:50 HIV-1 broadly neutralizing antibodies (bNAbs) in clinical trials Nono Mkhize NICD
10:50 - 11:15 The immunology of tuberculosis disease progression Tom Scriba University of Cape Town
11:15 - 11:40 Immune mechanisms of lung damage in TB Pholo Maenetje Aurum
11:40-11:50 Talks from submitted abstracts - Viral antibody repertoire in HIV-exposed but uninfected and HIV-unexposed uninfected infants at birth and 36 weeks of life Rachael Gachogo
11:50 - 12:40 Ethics talk Theresa Rossouw University of Pretoria

12:40 - 13:30 LUNCH
Session 10: At the surface Chair: Nancy Meulenberg
13:30 - 14:00 T cell mediated rejection responses in non-infectious placental villitis Elizabeth Enninga Mayo
14:00 - 14:25 Maternal events during pregnancy are reflected in the placenta Clive Gray SUN
14:25 - 14:50 Genital inflammation and the risk of HIV infection in women Lenine Liebenberg CAPRISA
14:50 - 15:15 The Heart of the Matter – the vascular endothelium as an immunological organ Elizabeth Mayne University of Cape Town
15:15 - 15:25 Talks from submitted abstracts - In utero human cytomegalovirus infection is associated with increased levels of putative protective maternal antibodies in nonprimary infection Sashkia Balla
15:25 - 15:35 Talks from submitted abstracts - Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality Sonwabile Dzanibe

15:35 Looking forward - IUIS 2023 Clive Gray
15:50 Vote of thanks and closing Catherine Worsley University of Pretoria